Comparison of Efficacy of Metformin Gel 30% vs Triple Combination Cream (Hydroquinone 4%, Flucinolone Acetonide 0.01%, Tretinoin 0.025%) in Treatment of Melasma in Tertiary Care Hospital Karachi

This study will compare two topical treatments for melasma. Participants will be randomly assigned to receive either triple combination cream (hydroquinone 2% + tretinoin 0.025% + fluocinolone acetonide 0.01%) or 30% metformin gel, applied once nightly for 12 weeks. All participants will use broad-spectrum sunscreen (SPF ≥30) during the daytime throughout the treatment period. Melasma severity will be assessed using the Melasma Area and Severity Index (MASI), and the study will determine which treatment is more effective and better tolerated at the end of 12 weeks.

NCT Number	NCT07345507
Lead Sponsor	Jinnah Postgraduate Medical Centre
Conditions	Melasma
Enrollment	34 participants
Start Date	2025-02-01
Primary Completion	2025-08-30 (estimated)
Study Completion	2025-08-30 (estimated)
Updated on ClinicalTrials.gov	2026-01-21