Stimulus Equivalence Learning in Acquired Brain Injury.

Stimulus Equivalence Learning (SEL) is a form of learning in which stimuli (such as words, pictures, or sounds) become linked to one another in memory, even though this specific connection has not been directly taught. In a typical SEL task, two relations are taught explicitly (A→B and A→C), and the untrained relation (B→C) is then tested. This indirect relation is not intentionally or consciously learned and is considered a form of implicit learning. The principle of stimulus equivalence learning is still rarely applied in cognitive rehabilitation after acquired brain injury (ABI), with the exception of a few small (N=1) treatment studies that have shown positive effects. However, it remains unclear to what extent ABI may affect the ability to acquire stimulus equivalence.

NCT Number	NCT07345481
Lead Sponsor	Klimmendaal Revalidatiespecialisten Collaborators: Donders Centre for Cognitive Neuroimaging
Conditions	Acquired Brain Injury (Including Stroke)
Enrollment	40 participants
Start Date	2026-01-29
Primary Completion	2026-06 (estimated)
Study Completion	2026-07 (estimated)
Updated on ClinicalTrials.gov	2026-05-22