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Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis

Name: Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis — clinical trial record (NCT07345325)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: RIFREE

StatusRecruiting

PhasePhase 3

SponsorNantes University Hospital

Started2026-06-11

View on ClinicalTrials.gov ↗

Amendment history

2026-07-25

Study Status, Contacts/Locations v2

Study sitesdetails revised at 14 of 31 sites

2026-06-16

Study Status, Contacts/Locations v1

Recruitment opened

Primary completion pushed: 2030-07 → 2030-12-11

Completion pushed: 2031-01 → 2031-06-11

Start dateestimated 2026-01→confirmed 2026-06-11

Study sitesdetails revised at 31 of 31 sites

2026-01-08

Original filing

Nantes University Hospital

356 trials monitored

See 13 trials at risk

The primary objective of this study is to demonstrate that a rifampin-free regimen is non-inferior to the rifampin-containing regimen in terms of all-cause mortality in staphylococcal prosthetic valve endocarditis within 6 months after randomization.

Trial Details

NCT Number	NCT07345325
Lead Sponsor	Nantes University Hospital
Conditions	Infective Endocarditis
Enrollment	422 participants
Start Date	2026-06-11
Primary Completion	2030-12-11 (estimated)
Study Completion	2031-06-11 (estimated)
Updated on ClinicalTrials.gov	2026-07-28