Melatonin Supplementation in Ovarian Response

Melatonin is a potent antioxidant, has been proposed to improve ovarian response and oocyte quality in assisted reproductive technologies (ART). This study evaluated the effects of melatonin supplementation on follicular fluid melatonin levels, hormonal profiles, and reproductive outcomes in women undergoing in vitro fertilization (IVF). Follicular fluid and serum melatonin levels, oocyte quality, embryo development, and pregnancy rates were assessed.

NCT Number	NCT07343947
Lead Sponsor	University of Sao Paulo General Hospital
Conditions	Infertility, Infertility (IVF Patients), Infertile Women Undergoing IVF or ICSI
Enrollment	80 participants
Start Date	2022-01-31
Primary Completion	2023-12-01 (estimated)
Study Completion	2023-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-15