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Investigation of the Impact of Myomectomy on Uterine Artery Doppler Velocimetry Findings

Study acronym: MYO-DOP
StatusCompleted
PhaseNot specified
Started
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Record History

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  1. Notable Primary endpoints: details revised at 1 of 3 entries Show 6 more changesShow less
    • Trial status changed: Enrolling by Invitation → Completed
    • Final enrollment: 50 participants (planned 70)
    • Primary and study completion dates changed from estimate of Feb 2026 to Feb 27, 2026
    • Eligibility criteria expanded, about 10 words
    • Study description revised
    • Publications: details revised at 4 of 4 entries
  2. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Objective: This scientific study aims to investigate whether myomectomy induces significant changes in uterine artery blood flow patterns. While Doppler ultrasonography is traditionally used to assess myoma vascularity, differential diagnosis (adenomyoma or sarcoma), and fertility impacts, there is a lack of prospective evidence comparing preoperative and postoperative uterine artery Doppler findings. Study Design and Rationale: The study will evaluate the hemodynamic influence of myomectomy by comparing flow measurements in the main uterine artery before and after surgical intervention. Existing literature has primarily focused on the correlation between myoma volume and vascular resistance; however, the direct impact of surgical removal of a myoma on uterine artery doppler velocimetry remains under-investigated. Participant Involvement: Participation is entirely voluntary, and participants may withdraw at any time without any impact on their medical care. Data collection involves routine clinical history, physical examination, and non-invasive ultrasound measurements. Clinical Significance: By establishing the effect of myoma removal on uterine blood supply, this research aims to provide guiding data for the follow-up and treatment planning of patients with leiomyomas. The findings may offer new insights into how surgical management restores or alters uterine hemodynamics, potentially influencing future diagnostic and therapeutic approaches.
Trial Details
NCT Number NCT07343765
Lead Sponsor Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Conditions
(from sponsor)
Leiomyoma (Uterine Fibroids), Myomectomy, Doppler Ultrasound
Related terms Leiomyoma
Enrollment 50 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov