Deep Brain Stimulation to Understand and Treat Addiction

This study is testing whether deep brain stimulation (DBS) can safely help people with severe alcohol use disorder who have not improved with standard treatments. DBS uses small electrical signals to change activity in brain areas linked to craving, self-control, and emotion. The study will test whether this treatment can reduce how often people drink and how much they drink each day. Researchers will also record brain activity to better understand how DBS affects craving and relapse.

NCT Number	NCT07341230
Lead Sponsor	University of Cambridge Collaborators: Cambridge University Hospitals NHS Foundation Trust, King's College Hospital NHS Trust
Conditions	Alcohol Use Disorder
Enrollment	9 participants
Start Date	2025-07-01
Primary Completion	2027-10-31 (estimated)
Study Completion	2027-10-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-24