Positional Effects on Lung Ventilation and Perfusion in Obesity

Electrical Impedance Tomography (EIT) is a non-invasive, bedside monitoring tool that provides real-time information on regional ventilation and perfusion. In particular, EIT has the potential to guide individualized mechanical ventilation in obese patients by revealing how gravitational and positional factors alter regional lung behavior. Assessing the effects of different horizontal positions on both ventilation and perfusion may help optimize respiratory management strategies tailored to body habitus. By comparing obese and non-obese healthy participants across different positions, this study aims to provide novel insights into the postural effects on lung aeration and perfusion distribution, and to highlight the role of EIT in tailoring individualized ventilation strategies.

NCT Number	NCT07341113
Lead Sponsor	Koç University
Conditions	Obesity (Disorder), Ventilation Homogeneity, Perfusion, Ventilation Perfusion Mismatch, Position Differences, Electrical Impedance Tomography (EIT)
Enrollment	40 participants
Start Date	2025-12-01
Primary Completion	2026-03-05 (estimated)
Study Completion	2026-03-05 (estimated)
Updated on ClinicalTrials.gov	2026-04-15