Hypersensitivity to Amylin in Post-Traumatic Headache

Pramlintide is a peptide analogue of human amylin which is a vasoactive substance involved in the pathogenesis of headache. This study investigates whether pramlintide induces migraine-like headache in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI).

NCT Number	NCT07340775
Lead Sponsor	Danish Headache Center
Conditions	Headache Disorders, Secondary, Brain Diseases, Headache Disorders, Nervous System Diseases, Central Nervous System Diseases, Neurologic Manifestations, Signs and Symptoms, Pathological Conditions, Signs and Symptoms +9 more
Enrollment	21 participants
Start Date	2026-02
Primary Completion	2028-12 (estimated)
Study Completion	2028-12 (estimated)
Updated on ClinicalTrials.gov	2026-01-14