Helicobacter Pylori Infection and Gastric Diseases in Lao PDR: First Community-Wide Population-Based Study

This study aims to determine the regional prevalence of Helicobacter pylori infection, bacterial strain differences, and the prevalence of gastric cancer in two provinces of Laos, a multi-ethnic country where these factors may vary by region and ethnicity. The study also evaluates whether H. pylori eradication therapy contributes to disease prevention. Residents aged 18 years or older in Luang Prabang Province and Champasak Province underwent stool antigen testing, and H. pylori-positive individuals received eradication therapy. High-risk participants aged ≥40 years underwent upper gastrointestinal endoscopy for early detection of gastric cancer.

NCT Number	NCT07340593
Lead Sponsor	Zero Helicobacter IGAN Network Collaborators: Oita University, Setthathirath Hospital, Mahosot Hospital, Laos, Lao National Cancer Center
Conditions	Gastric Cancer Screening, Prevention and Control, Helicobacter Eradication, Helicobacter Infections
Enrollment	1,251 participants
Start Date	2023-12-18
Primary Completion	2024-10-10 (estimated)
Study Completion	2025-06-07 (estimated)
Updated on ClinicalTrials.gov	2026-01-14