Physiological and Biochemical Responses to Blood Flow Restriction Training

This study is designed to examine the short-term and long-term effects of blood flow restriction exercise training on physiological and biochemical markers in individuals who are new to strength training and in experienced athletes training at different load levels. This exercise method involves placing a special inflatable cuff around the upper part of the thigh. The cuff partially limits blood flow to the area, which helps the muscles work more effectively during exercise. The cuff will be applied only to the individual's dominant leg (the leg you use more often in daily activities), but all exercises will be performed using both legs. The exercise program will last for a total of six weeks and will be carried out twice per week. The pressure applied by the cuff will be individually adjusted based on each participant's physical characteristics to ensure safety and comfort. The study will include a total of 30 healthy participants aged between 18 and 40 years. Participants will be divided into two groups: individuals who have recently started strength training and experienced athletes with different levels of training experience.

NCT Number	NCT07340385
Lead Sponsor	Afyonkarahisar Health Sciences University Collaborators: Kocatepe University
Conditions	Healthy Individuals, Trained Athletes
Enrollment	30 participants
Start Date	2026-01-20
Primary Completion	2027-01-20 (estimated)
Study Completion	2027-03-20 (estimated)
Updated on ClinicalTrials.gov	2026-02-13