Physiological Reference Values of Total Arterial Impedance Derived From PRAM Monitoring

Total arterial impedance (Ztot) is an advanced hemodynamic parameter that reflects the global arterial load opposing ventricular ejection by integrating both steady and pulsatile components of the arterial system. Although Ztot can be continuously derived from Pressure Recording Analytical Method (PRAM)-based monitoring, physiological reference values under stable clinical conditions are not well established. This observational study aims to define patient-level physiological reference values for Ztot using intraoperative hemodynamic data obtained from PRAM-based arterial waveform analysis during hemodynamically stable periods. In addition, the study evaluates the associations between Ztot and key hemodynamic variables reflecting arterial load and cardiovascular performance. High-resolution intraoperative data routinely recorded during standard clinical care are retrospectively analyzed. The findings of this study are intended to improve the interpretability of Ztot in advanced hemodynamic monitoring and to support future clinical and research applications.

NCT Number	NCT07340333
Lead Sponsor	Ataturk University
Conditions	Intraoperative Hemodynamics
Enrollment	437 participants
Start Date	2026-01-30
Primary Completion	2026-02-02 (estimated)
Study Completion	2026-02-02 (estimated)
Updated on ClinicalTrials.gov	2026-02-04