Digital vs. Analog Inputs in CAD/CAM Orthodontics: A Comparative Clinical Evaluation of Palatal Expander Fabrication Workflow

36 patients with unilateral or bilateral cross bite treated with hyrax expanders fabricated through three distinct workflows: fully conventional (physical impression + manual fabrication), hybrid (physical impression + CAD/CAM fabrication), and fully digital (intraoral scanning + CAD/CAM fabrication). To evaluate and compare the clinical fit, workflow efficiency, and patient/clinician satisfaction of palatal expanders fabricated using traditional, hybrid digital, and fully digital workflows.

NCT Number	NCT07338591
Lead Sponsor	Mansoura University
Conditions	Transverse Maxillary Deficiency
Enrollment	36 participants
Start Date	2025-12-25
Primary Completion	2027-01-25 (estimated)
Study Completion	2027-07-25 (estimated)
Updated on ClinicalTrials.gov	2026-01-14