Methotrexat to Hand Eczema in the BIOSKIN Cohort

Handeczema is a common chronic skin disease that markedly affect health and quality of life. Effective treatment is limited by the lack of biomarkers that can predict disease course, comorbidities and treatment response. This study is is an observational, prospective, study of patients initiating treatment with methotrexat at the Department of Dermatology and Allergy at Herlev- and Gentofte Hospital. The main aim is to study the clinical effect of methotrexat in patients with hand eczema. Secondary aims are to study drug survival, reasons for termination of treatment and side effects.

NCT Number	NCT07338305
Lead Sponsor	Lone Skov Collaborators: University of Copenhagen, Herlev and Gentofte Hospital
Conditions	Atopic Dermatitis, Contact Dermatitis, Hand Eczema
Enrollment	50 participants
Start Date	2025-11-01
Primary Completion	2026-09 (estimated)
Study Completion	2026-12 (estimated)
Updated on ClinicalTrials.gov	2026-01-13