Clinical Trial

Study to Assess the Safety and Pharmacokinetics of AVD275 Injection in Patients With Osteoarthritis of the Knee

Recruiting Phase 1
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Summary
This study aims to understand the safety, drug concentration and distribution of an intra-articular injectable formulation of celecoxib, AVD275, in patients with knee osteoarthritis. One single injection at three different doses of the drug will be studied in a sequential order, and each participant will be monitored for 24 weeks over ten clinical visits.
Protocol Amendment History 1 change
critical Recruitment opened 2026-04-01
Trial Details
NCT Number NCT07338266
Lead Sponsor Avidence Therapeutics
Conditions Osteoarthritis of the Knee
Enrollment 15 participants
Start Date 2026-01-22
Primary Completion 2026-12 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2026-03-31