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Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage

Study acronym: MISTICH
StatusRecruiting
PhasePhase 3
Started2026-04-02
View on ClinicalTrials.gov ↗

Amendment history

2026-04-19
Study Status, Sponsor/Collaborators, Eligibility, Contacts/Locations v1
Recruitment opened
Trial sites expanded: 1 → 41 locations
Start dateestimated 2026-01→confirmed 2026-04-02
Eligibility criteria+25 characters
[...] dural hemorrhage; Patients with uncontrollable hypertension or( thosesystolic atblood highpressure riskpersistently of≥ hematoma180 expansionmmHg indicateddespite byintensive imagingantihypertensive signstreatment); Progressive neurological or other severe systemic diseases [...]
2026-01-03
Original filing
This is a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial. It aims to evaluate the efficacy and safety of oral minocycline in patients with acute spontaneous intracerebral hemorrhage within 48 hours of onset.
Trial Details
NCT Number NCT07338175
Lead Sponsor Beijing Tiantan Hospital
Conditions Intracerebral Hemorrhage
Enrollment 1,192 participants
Start Date 2026-04-02
Primary Completion 2028-06 (estimated)
Study Completion 2028-12 (estimated)
Updated on ClinicalTrials.gov 2026-04-23