Characterization of Weaning Practices in ICUs of Global South Countries

This is a prospective observational study to be conducted in intensive care units of Global South countries. Patients on mechanical ventilation for more than 12 hours who have initiated the weaning process and for whom the attending team plans extubation within the next 6 hours will be included. Data will be collected for each patient during the first 7 days after extubation, with follow-up until hospital discharge or death. We plan to conduct the study in intensive care units from Global South countries (low- and middle-income countries predominantly located in the Southern Hemisphere, though some in the Northern Hemisphere are also considered).

NCT Number	NCT07337408
Lead Sponsor	Hospital do Coracao
Conditions	Weaning From Mechanical Ventilation, Weaning Failure, Weaning From Mechanical Ventilation, Extubation
Enrollment	900 participants
Start Date	2026-02
Primary Completion	2027-03 (estimated)
Study Completion	2027-04 (estimated)
Updated on ClinicalTrials.gov	2026-02-12