Clinical Trial

Paclitaxel Polymersomes + Carboplatin + Adebelimab: Neoadjuvant Phase Ⅱ Single-Arm Study for Resectable Mucosal Melanoma

Recruiting Phase 2
View on ClinicalTrials.gov →
Summary
The primary objective of this study is to evaluate the pathological response rate of neoadjuvant therapy with paclitaxel polymersomes for injection combined with carboplatin and adebrelimab in patients with resectable mucosal melanoma.Subjects will receive the combination therapy of paclitaxel polymersomes for injection, carboplatin and adebrelimab prior to surgery, with a treatment cycle of 3 weeks and a total of 3 cycles.After completing 3 cycles of treatment, subjects will undergo curative surgery. Pathologists will evaluate the surgically resected specimens to determine the status of pathological response, and immunohistochemical assays will be performed to assess the intensity of immune activation within the tumor microenvironment.
Trial Details
NCT Number NCT07336979
Lead Sponsor Sun Yat-sen University
Conditions Resectable Mucosal Melanoma
Enrollment 32 participants
Start Date 2025-03-20
Primary Completion 2027-03-20 (estimated)
Study Completion 2027-03-20 (estimated)
Updated on ClinicalTrials.gov 2026-01-13