HVNI vs CPAP in Children With Acute Respiratory Distress

Acute breathing problems are a common reason for children to be admitted to the pediatric intensive care unit, and many of these children need breathing support without a breathing tube. High-Velocity Nasal Insufflation (HVNI) and nasal Continuous Positive Airway Pressure (nCPAP) are commonly used to help children breathe, but there is limited information comparing how well they work and how comfortable they are for children. This study aims to compare the clinical outcomes and tolerability of HVNI and nCPAP in children aged 1 month to 5 years with acute respiratory distress admitted to the pediatric intensive care unit, using clinical assessment and lung ultrasound findings.

NCT Number	NCT07336121
Lead Sponsor	Ain Shams University
Conditions	Community Acquired Pneumonia, Bronchiolitis
Enrollment	80 participants
Start Date	2023-01-09
Primary Completion	2024-12-01 (estimated)
Study Completion	2024-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-27