Dynamical Electrophysiology and Neuropathology in Lewy's Bodies Disease

Lewy body disease (LBD) is a neurodegenerative disorder that causes cognitive and behavioral problems. However, it is difficult to diagnose, and its pathophysiology is still not fully understood. The usual diagnostic criteria for LBD have excellent specificity but poor sensitivity. In particular, we lack paraclinical tests that can make a significant contribution. LBD patients may exhibit abnormalities in brain activity dynamics, which can be detected by EEG and may be linked to neuronal dysfunctions specific to the disease. The objective of this study is twofold: first, to assess the validity of this observation, that is, to confirm that the observed phenomenon is indeed linked to the pathophysiology of LBD, and second, to clarify the nature of these abnormalities by exploring the brain dynamics of LBD patients in greater detail.

NCT Number	NCT07335692
Lead Sponsor	University Hospital, Strasbourg, France
Conditions	Lewy Body Disease
Enrollment	40 participants
Start Date	2025-06-02
Primary Completion	2026-06 (estimated)
Study Completion	2026-06-02 (estimated)
Updated on ClinicalTrials.gov	2026-01-13