A Study to Learn if Itraconazole Changes How the Body Processes PF-07248144 (Study Medicine)

The purpose of the study is to learn how itraconazole changes how the body processes the study medicine called PF-07248144. The study will also look at the safety, tolerability, and how PF-07248144 is changed and removed from the body after taking PF-07248144 alone compared to when it is taken with itraconazole. Itraconazole can change how your body processes some medications so it may change the body's processing of PF-07248144. Multiple blood samples will be collected after each dose of PF-07248144 to determine how much PF-07248144 is in the blood at different times. This will help characterize the pharmacokinetics (pharmacokinetics helps us understand how the drug is changed and eliminated from your body after you take it) of PF-07248144 alone and when taken with itraconazole.

NCT Number	NCT07335419
Lead Sponsor	Pfizer
Conditions	Healthy Adult Participants
Enrollment	12 participants
Start Date	2026-01-02
Primary Completion	2026-02-22 (estimated)
Study Completion	2026-03-21 (estimated)
Updated on ClinicalTrials.gov	2026-03-19