Emotional Well-being and Measures of Healthy Aging

This randomized control study is designed to understand the role of a positive psychology intervention (PARK: Positive Affect Regulation sKills) in biological aging and well-being. PARK provides a series of positive emotion skills in a self-guided online format, making the program accessible and convenient. Our main aims are: Aim 1: To explore the effects of PARK on psychological well-being (e.g., depression, anxiety, positive affect). Aim 2: To explore the effects of PARK on biological age as defined by DNA methylation (DNAm) GrimAge and electrocardiogram-age (ECG-age), as well as physiological well-being in adults (e.g., cardiovascular, endocrine, musculoskeletal functioning, etc.).

NCT Number	NCT07334106
Lead Sponsor	Northwestern University Collaborators: Potocsnak Human Longevity Lab
Conditions	Aging, Aging, Healthy, Aging Well, Aging, Biological
Enrollment	80 participants
Start Date	2025-09-01
Primary Completion	2028-08 (estimated)
Study Completion	2028-08 (estimated)
Updated on ClinicalTrials.gov	2026-01-12