Clinical Trial

Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment

Recruiting
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Record status
This record was last updated January 12, 2026 (before its estimated March 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
Oral leukoplakia (OL) is recognized as the most common potentially malignant disorder of the oral mucosa. The pathogenesis of OL is complex and multifactorial, with oxidative stress playing a central role. Topical antioxidants have gained attention as therapeutic options to help stabilize lesions and potentially prevent malignant transformation. Both CoQ10 and curcumin have demonstrated a clinical success as strong antioxidants showing their capacity to reduce the lesion size and to stabilize the disease, ultimately preventing progression into oral malignancy. Aim: This study aims to clinically and biochemically assess the effectiveness of topical Coenzyme Q10 and Curcumin in the management of homogeneous oral leukoplakia.
Trial Details
NCT Number NCT07331935
Lead Sponsor Alexandria University
Conditions Oral Leukoplakia
Enrollment 34 participants
Start Date 2025-11-25
Primary Completion 2026-03-30 (estimated)
Study Completion 2026-03-30 (estimated)
Updated on ClinicalTrials.gov 2026-01-12