Retention of Pits and Fissure Sealants on Non Carious vs Initial Carious Enamel Lesions in Posterior Teeth

This clinical study is planned to be conducted to compare retention rates of pits and fissure sealants on non carious (ICDAS score 0) vs Initial carious enamel lesions (ICDAS Score 1,2) in posterior permeant teeth at 3 months, 6 months and 12 months follow-up. This will help us guide follow-up strategies for optimal caries prevention.

NCT Number	NCT07330089
Lead Sponsor	Foundation University Islamabad
Conditions	Dental Enamel, Dental Enamel Hypomineralization, Dental Enamel Hypoplasia
Enrollment	420 participants
Start Date	2025-12-27
Primary Completion	2027-06 (estimated)
Study Completion	2027-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-26