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Crystalloid vs Colloid for Hemodynamics During Anesthesia Induction in TAVR Patients

Study acronym: CHAIN-T
StatusNot Yet Recruiting
PhaseNot applicable
Started
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Record History

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  1. Secondary endpoints: details revised at 1 of 8 entriesv3
  2. Start date: Jan 4, 2026 to Feb 16, 2026
    • Primary endpoint revised
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The purpose of this study is to evaluate whether the administration of 5 ml/kg of colloid solution prior to anesthesia induction, compared with 5 ml/kg of lactated Ringer's solution, can reduce hemodynamic fluctuations during the induction period (defined as the first 15 minutes after induction) in patients undergoing Transcatheter Aortic Valve Replacement (TAVR).
Trial Details
NCT Number NCT07329660
Lead Sponsor Air Force Military Medical University, China
Conditions
(from sponsor)		 Transcatheter Aortic Valve Replacement, Hemodynamic Stability, Anesthesia Induction
Enrollment 116 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov