Clinical Trial

Evaluation of Neoadjuvant Stereotactic Radiosurgery (SRS) and Multi-fraction SRS Alone for the Treatment of Large Brain Metastases

Study acronym: RENESANS
Not Yet Recruiting Phase 3
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Summary
The prospective, two-arm, randomized, controlled, multicentric phase III RENESANS trial is designed to compare the efficacy and safety of neoadjuvant stereotactic radiosurgery (Neo-SRS) versus multi-fraction stereotactic radiosurgery (mfSRS) in patients with large brain metastases, with the primary objective of evaluating the incidence of central nervous system composite events.
Trial Details
NCT Number NCT07329634
Lead Sponsor Maciej Harat
Collaborators: Bydgoszcz University of Science and Technology
Conditions Brain Metastasis
Enrollment 98 participants
Start Date 2026-01
Primary Completion 2029-09 (estimated)
Study Completion 2032-09 (estimated)
Updated on ClinicalTrials.gov 2026-01-09