Femoral Nerve Mobilization for Patients With Knee Osteoarthritis

Background: Knee osteoarthritis (KO) is considered as a cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality. There is a limited knowledge about using femoral nerve mobilization in treating patients with arthritic changes. Objectives: This study will be designed to determine the efficacy of adding of femoral nerve mobilization on pain intensity, function, quality of life and central sensitization in patients with knee osteoarthritis Methods: Thirty patients (aged ≥50 years with KO Kellgren-Lawrence grades I-II) will be included in this study: Patients will randomly be assigned into two groups: group A will receive traditional physical therapy while group B will receive femoral nerve mobilization in addition to traditional physical therapy. Three sessions will be performed for four weeks by 3 session /week. Patients will be evaluated for pain intensity using the numerical rating scale (NRS), knee function by WOMAC scale, quality of life by 12-item Short Form Survey questionnaire (SF-12) and central sensitization by the Arabic version of central sensitization inventory (CSI).

NCT Number	NCT07329205
Lead Sponsor	Prince Sattam Bin Abdulaziz University
Conditions	Knee Osteoarthristis
Enrollment	50 participants
Start Date	2025-12-20
Primary Completion	2026-02-10 (estimated)
Study Completion	2026-02-25 (estimated)
Updated on ClinicalTrials.gov	2026-01-09