Clinical Trial

Antibiotics Distribution Study in Peripheral Compartments: Contribution of Microdialysis

Study acronym: Antimidis
Not Yet Recruiting
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Record status
This record was last updated January 8, 2026 (before its estimated February 2026 completion). Its status may not reflect the trial's current state.
Summary
Postoperative mediastinitis is an important cause of postoperative morbidity in children. The main objective of this study is to describe the distribution of cefazolin, using as surgical antibiotic prophylaxis, in the mediastinal compartment in children after cardiac surgery for congenital heart disease. The investigators aims to build a population pharmacokinetic model of cefazolin using plasma and tissue concentrations in order to optimize and individualize cefazolin dosing regimens. Cefazolin tissue pharmacokinetics will use a microdialysis procedure.
Trial Details
NCT Number NCT07327502
Lead Sponsor Assistance Publique - Hôpitaux de Paris
Collaborators: URC-CIC Paris Descartes Necker Cochin
Conditions Children in Cardiac Intensive Care Requiring Surgery for Congenital Heart Disease
Enrollment 10 participants
Start Date 2026-01
Primary Completion 2026-02 (estimated)
Study Completion 2027-02 (estimated)
Updated on ClinicalTrials.gov 2026-01-08