Hybrid Assistive Limb Application in Multiple Sclerosis Patients

The Hybrid Assistive Limb (HAL) exoskeleton detects bioelectrical signals from the muscles, responds to the intention of voluntary movement, and provides biological feedback. In this study, the effects of HAL application on walking performance and balance in patients with multiple sclerosis will be examined in a single-center, controlled design. Participants will undergo walking rehabilitation with HAL for 1 hour per day, 5 days a week, for a total of 2 months. Walking and balance performance will be assessed before and after the intervention using the 10-Minute Walk Test (10MWT) to measure maximum walking speed, the 6-Minute Walk Test (6MWT) to evaluate walking endurance and cardiorespiratory performance, and the Timed Up and Go Test (TUG) to assess functional mobility and dynamic balance. Additionally, walking parameters and static balance will be measured using Tecnobody systems. Appropriate statistical tests will be applied, and a significance level of p\<0.05 will be considered.

NCT Number	NCT07326852
Lead Sponsor	Ege University
Conditions	Multiple Sclerosis
Enrollment	13 participants
Start Date	2025-10-08
Primary Completion	2025-12-09 (estimated)
Study Completion	2026-02-09 (estimated)
Updated on ClinicalTrials.gov	2026-07-07