Effects of Spinal vs General Anesthesia on Systemic Inflammation in PCNL

This observational study aims to compare the effects of spinal and general anesthesia on perioperative systemic inflammatory response in patients undergoing percutaneous nephrolithotomy (PCNL). Systemic inflammatory indices derived from routine complete blood count parameters, including Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), Neutrophil-to-Lymphocyte Ratio (NLR), and Red Cell Distribution Width (RDW), will be evaluated. Preoperative and postoperative laboratory values will be analyzed to determine whether the type of anesthesia influences systemic inflammatory markers and related clinical outcomes.

NCT Number	NCT07326670
Lead Sponsor	Elazıg Fethi Sekin Sehir Hastanesi
Conditions	Anesthesia Techniques, Percutaneous Nephrolithotomy, Systemic Inflammation
Enrollment	90 participants
Start Date	2025-11-07
Primary Completion	2026-04-25 (estimated)
Study Completion	2026-04-25 (estimated)
Updated on ClinicalTrials.gov	2026-06-22