Prevalence of Large Vessel Occlusion among acute ischemic stroke patients in Assiut University hospitals
1. Study Objectives
Primary Objective:
\- To determine the prevalence of LVO among acute ischemic stroke (AIS) patients presenting to Assiut University hospitals
Secondary Objectives:
* To describe clinical and radiological characteristics of LVO patients.
* To assess factors associated with LVO (age, sex, stroke severity, comorbidities).
2. Study Design
* Type: single center, prospective observational cross-sectional study
* Duration: 12-month recruitment period
* Setting: Assiut university hospitals, stroke unit.
3. Study Population
Inclusion Criteria:
* Adults (≥18 years)
* Diagnosed with acute ischemic stroke within 24 hours of symptom onset
* Underwent vascular imaging (CTA or MRA) on admission
Exclusion Criteria:
* Hemorrhagic stroke
* Stroke mimics
* Incomplete imaging data 4. Definitions
Large Vessel Occlusion (LVO) defined as occlusion in:
* Intracranial ICA
* M1 or proximal M2 segments of MCA
* Basilar artery ± Optional: A1 6. Data Collection
Clinical Data:
* Demographics (age, sex)
* Risk factors (HTN, DM, AF, CAD, smoking)
* NIHSS on admission and discharge mRS on admission and discharge
* Onset-to-door time
* Imaging modality used
Imaging Data:
* Site of occlusion
* ASPECTS (optional)
* Collateral status (optional if available)
Hospital Data:
* Facility type (public vs private)
* Door-to-CT and door-to-CTA times 8. Analysis Plan
* Primary: Prevalence of LVO = Number of LVO cases / Total AIS patients with vascular imaging
* Subgroup analysis: By age group, sex, region, NIHSS
* Secondary: Logistic regression to identify predictors of LVO