Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation

This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation. Magnesium sulfate has been reported to have potential bronchodilatory and anti-inflammatory properties, which may improve gas exchange and respiratory mechanics during lung isolation. In this study, patients who receive magnesium sulfate as part of standard anesthetic management will be compared with those who do not receive the drug. Oxygenation parameters, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. The findings of this study may help clarify whether magnesium sulfate provides measurable respiratory benefits during one-lung ventilation.

NCT Number	NCT07325773
Lead Sponsor	Marmara University
Conditions	Intraoperative Oxygenation and Pulmonary Mechanics
Enrollment	104 participants
Start Date	2025-12-01
Primary Completion	2026-07-15 (estimated)
Study Completion	2026-11-28 (estimated)
Updated on ClinicalTrials.gov	2026-01-08