Safety and Efficacy of N-Acetylcysteine Mouthwash in Prevention of Mucositis in HSCT Patients

Oral mucositis (OM) is one of the most frequent complications in patients who undergo HSCT. It not only causes severe discomfort but also affects treatment adherence and increases hospital stays. In this study, we aim to assess whether using N-acetylcysteine mouthwash can safely and effectively prevent OM. The trial is randomized and conducted in the hematology wards of TUMS-affiliated RIOHCT, including both autologous and allogeneic HSCT patients.

NCT Number	NCT07325383
Lead Sponsor	Tehran University of Medical Sciences Collaborators: Research Institute for Oncology- Hematology and Cell Therapy (RIOHCT), Tehran University of Medical Sciences, Iran
Conditions	Oral Mucositis, Hematopoietic Stem Cell Transplantation (HSCT)
Enrollment	106 participants
Start Date	2024-08-18
Primary Completion	2025-03-08 (estimated)
Study Completion	2026-02 (estimated)
Updated on ClinicalTrials.gov	2026-01-08