Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery

Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear. This prospective cohort study aims to evaluate the association between intraoperative hemodynamic instability (defined as MAP \< 65 mmHg or vasopressor requirement) and major postoperative complications (Delirium, Acute Kidney Injury, Stroke, or Mortality) in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass.

NCT Number	NCT07324694
Lead Sponsor	Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Conditions	Cardiac Surgery, Intraoperative Hemodynamic Instability, Postoperative Complication, Acute Kidney Injury, Postoperative Delirium (POD)
Enrollment	230 participants
Start Date	2025-04-26
Primary Completion	2026-08-20 (estimated)
Study Completion	2026-09-05 (estimated)
Updated on ClinicalTrials.gov	2026-07-29