CTG vs VCMX for Peri-implant Soft Tissue Thickness

This investigator-initiated randomized controlled clinical trial evaluated changes in peri-implant soft tissue thickness in the aesthetic zone following soft tissue augmentation. Adult patients requiring single-tooth implant therapy in the aesthetic zone were randomly assigned to receive either an autogenous connective tissue graft (CTG) or a volume-stable collagen matrix (VCMX) at the implant site. The primary objective of the study was to compare changes in peri-implant soft tissue thickness between the two treatment approaches over time. Secondary objectives included evaluation of aesthetic outcomes, clinical parameters, and treatment-related complications. The study was conducted at a single academic clinical center in Poland in accordance with Good Clinical Practice, the Declaration of Helsinki, and applicable ethical and regulatory requirements. All participants provided written informed consent prior to enrollment.

NCT Number	NCT07324187
Lead Sponsor	Medical Innovation Center Wroclaw Collaborators: Geistlich Pharma AG
Conditions	Dental Implants, Peri-Implant Tissues, Missing Tooth/Teeth
Enrollment	36 participants
Start Date	2022-01-02
Primary Completion	2025-04-10 (estimated)
Study Completion	2025-04-19 (estimated)
Updated on ClinicalTrials.gov	2026-01-16