Multi-Modal Longevity Protocol Including Autologous Cell-Free Conditioned Media

This pilot study evaluated a multi-modal longevity protocol combining lifestyle optimisation, nutritional supplementation, and autologous cell-free conditioned media derived from peripheral blood-derived pro-regenerative cells (APRC-CM). Fourteen healthy adult participants completed a 17-week programme including baseline and post-intervention biomarker assessments. The primary objective was to characterise changes in biological age using DNA methylation-based epigenetic clocks, PhenoAge and other physiological and biochemical markers.

NCT Number	NCT07322224
Lead Sponsor	BlueBird Age Reversal SA Collaborators: xLongevity, Wellbeing International Foundation
Conditions	Biological Aging, Healthy Aging, Longevity
Enrollment	15 participants
Start Date	2024-08-05
Primary Completion	2024-12-15 (estimated)
Study Completion	2025-03-20 (estimated)
Updated on ClinicalTrials.gov	2026-01-07