Light Fasting Diet and Magnesium in Polycystic Ovary Syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age, which is associated with hormonal imbalances, dyslipidemia, chronic inflammation, and increased oxidative stress, and can increase the risk of cardiovascular and metabolic diseases. Evidence suggests that nutritional interventions play an important role in improving metabolic outcomes in these patients. This study is a randomized, triple-blind, controlled clinical trial designed to investigate the effect of a light fasting diet combined with magnesium supplementation on lipid profile, lipid peroxidation (malondialdehyde), and C-reactive protein (CRP) levels in women with PCOS. In this study, 46 eligible women were randomly divided into two groups receiving a light fasting diet with magnesium supplementation or placebo, and changes in biochemical and anthropometric indices were evaluated before and after 8 weeks of intervention.

NCT Number	NCT07322120
Lead Sponsor	Behnood Abbasi
Conditions	Polycystic Ovary Syndrome
Enrollment	46 participants
Start Date	2026-02-20
Primary Completion	2026-05-22 (estimated)
Study Completion	2026-06-22 (estimated)
Updated on ClinicalTrials.gov	2026-01-07