Radical Nephroureterectomy With vs Without Template Lymph Node Dissection in High-Risk Upper Tract Urothelial Carcinoma (T-LND UTUC)

The goal of this clinical trial is to learn if adding a template lymph node dissection (TLND) to the standard surgery for upper tract urothelial cancer (UTUC) can improve patient survival and prevent the cancer from recurrence. The main questions it aims to answer are: Do patients who receive standard surgery with LND live longer without their cancer returning? Is adding LND safe, and how does it affect surgery-related complications? Researchers will compare the group receiving standard surgery plus LND to the group receiving standard surgery alone to see if adding LND is more effective. Participants will: Be randomly assigned to one of the two surgical groups. Undergo their assigned surgery and recover in the hospital. Attend regular follow-up visits for checkups and scans for 5 years to monitor for cancer recurrence, with the possibility of long-term follow-up extending to 10 years.

NCT Number	NCT07321210
Lead Sponsor	Tianjin Medical University Second Hospital Collaborators: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Sun Yat-Sen University Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin Third Central Hospital
Conditions	Upper Tract Urothelial Carcinoma, Lymph Node Dissection
Enrollment	150 participants
Start Date	2025-09-01
Primary Completion	2027-08-30 (estimated)
Study Completion	2032-08-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-25