Fibrin-Enhanced TIP Versus Grafted TIP Urethroplasty in Distal Hypospadias

Hypospadias is a common congenital condition in boys in which the opening of the urethra is located on the underside of the penis. Distal hypospadias is the most common form and is usually treated surgically using tubularized incised plate (TIP) urethroplasty. In boys with an unfavorable urethral plate, graft-augmented techniques (G-TIP) are often used; however, postoperative complications such as urethrocutaneous fistula and narrowing of the urethral opening (meatal stenosis) may still occur. Platelet-rich fibrin (PRF) is a biological material obtained from the patient's own blood that contains natural growth factors and may help improve tissue healing. This study aims to evaluate whether the use of PRF during surgery can reduce postoperative complications and improve surgical outcomes in children undergoing hypospadias repair.

NCT Number	NCT07319780
Lead Sponsor	National Children's Medical Center, Uzbekistan Collaborators: Dr Cipto Mangunkusumo General Hospital
Conditions	Distal Hypospadias, Hypospadias
Enrollment	100 participants
Start Date	2026-01-05
Primary Completion	2028-07-05 (estimated)
Study Completion	2028-12-25 (estimated)
Updated on ClinicalTrials.gov	2026-01-30