Clinical Trial

Cerclage and Progesterone for Twin Pregnancies

Completed Phase 2
View on ClinicalTrials.gov →
Summary
Twin pregnancies face a high risk of complications, most notably preterm birth (delivery before 37 weeks), which is a major cause of infant death and illness globally. For women carrying twins who are identified as having a short cervical length (cervix measuring 25 millimeters or less), there is currently no single, highly effective preventative treatment. This study is a randomized clinical trial designed to determine if a combined therapy of Cervical Cerclage (a surgical stitch to support the cervix) and Vaginal Progesterone (a hormone medication) is more effective than standard care in preventing preterm birth and improving the overall health outcomes for both the mother and the babies. The trial will also investigate the biological basis of this effect by measuring specific inflammation markers (cytokines like Interleukin-1$\\beta$, 6, 8, and Tumor Necrosis Factor-α) in the cervical fluid before and after the intervention, to see if the combined treatment helps to reduce harmful local inflammation.
Trial Details
NCT Number NCT07319715
Lead Sponsor Benha University
Conditions Twin Pregnancy With Antenatal Problem
Enrollment 59 participants
Start Date 2023-01-20
Primary Completion 2024-08-24 (estimated)
Study Completion 2025-06-14 (estimated)
Updated on ClinicalTrials.gov 2026-01-06