Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.

The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor. Adopting a double-blind repeated measures cross-over design, middle-aged females (40-60 years) will be recruited to take part in a two-stage research study that will examine whether the formulation enhances cognitive performance and subjective well-being following the challenge of a stressor, compared to placebo. Cognitive assessments will examine the impact of the nutritional formulation on working memory, sustained attention, cognitive flexibility and inhibitory control. The study will also assess physiological (heart rate, blood pressure and cortisol) and subjective (well-being, anxiety, positive and negative mood, stress) markers of stress reactivity. The study will also explore levels sleep quality, mental and physical fatigue, effort, productivity, and perceived impact of the intervention.

NCT Number	NCT07319117
Lead Sponsor	Leeds Beckett University Collaborators: Sköshify™ Corporate HQ, 7045 Quiet Retreat Court, Niwot, CO 80503-7174
Conditions	Cognitive Assessment, Working Memory, Executive Function (Cognition), Sustained Attention, Inhibitory Control, Cognitive Flexibility, Cortisol, Stress +9 more
Enrollment	40 participants
Start Date	2025-12-15
Primary Completion	2026-08-01 (estimated)
Study Completion	2026-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-01-06