Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder

The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder. Neuroimaging before and after stimulation will establish the neural correlates of recovery and allow predictions of outcomes, which will be assessed throughout the study and one month after its completion. Results could pave the way towards development of a new self-administered intervention to reduce craving when it is needed the most, enhancing recovery real-time and in the natural environment in people with cocaine addiction as generalizable to other drugs of abuse and other disorders of self-control.

NCT Number	NCT07318480
Lead Sponsor	Icahn School of Medicine at Mount Sinai Collaborators: National Institute on Drug Abuse (NIDA), Soterix Medical
Conditions	Cocaine Use Disorder, Cocaine Dependence, Substance Use Disorder (SUD)
Enrollment	120 participants
Start Date	2026-02-25
Primary Completion	2030-02 (estimated)
Study Completion	2030-02 (estimated)
Updated on ClinicalTrials.gov	2026-03-03