Remote Ischemic Conditioning for Cognitive Impairment in Cerebral Small Vessel Disease

This randomized, double-blind, sham-controlled trial aims to evaluate the effect of remote ischemic conditioning (RIC) on cognitive function in patients with cerebral small vessel disease-related mild cognitive impairment. Forty eligible participants will be randomized 1:1 to receive either RIC or sham RIC twice daily for 90 days in addition to standard medical therapy. The primary outcome is the change in Montreal Cognitive Assessment (MoCA) score from baseline to 90 days. Secondary outcomes include changes in white matter hyperintensity burden and diffusion tensor imaging metrics on MRI, EEG functional connectivity, and activities of daily living.

NCT Number	NCT07317557
Lead Sponsor	Jiangsu Province Nanjing Brain Hospital
Conditions	Cerebral Small Vessel Disease, Cognitive Impairment
Enrollment	40 participants
Start Date	2026-04-01
Primary Completion	2026-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-10