The NTU JO-SMART Study

This study recruits patients with coexisting obesity and knee osteoarthritis (KOA) to implement the NTU-JO Smart Program, an innovative intervention integrating AI-assisted community-based exercise with continuous glucose monitoring (CGM). The primary objective is to investigate whether this intervention can improve glycemic control in this comorbid population. Other outcome measures include the risk of total knee arthroplasty (TKA), body weight changes, pain intensity scores, bone mineral density (BMD), cognitive function, as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Patient-Reported Outcomes Measurement Information System (PROMIS) scores, which reflect the patients' overall functional status. The project also sought to explore the long-term association of the NTU-JO Smart Program with the development of type 2 diabetes (T2D) and major renal events, thereby facilitating patient-centered early treatment.

NCT Number	NCT07317310
Lead Sponsor	National Taiwan University Hospital Collaborators: National Science and Technology Council, Taiwan
Conditions	Knee Osteoarthristis, Diabetes (DM), Obesity & Overweight, Chronic Kidney Disease
Enrollment	312 participants
Start Date	2026-08-01
Primary Completion	2029-12-31 (estimated)
Study Completion	2035-07-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-24