Preoptimisation in Ventral Hernia Surgery

The study is a multicentre, single-blinded, randomised controlled trial. Ventral hernia patients with an aperture width between four and eight centimetres are randomised to either participation in a multimodal preoptimisation programme, including interventions to increase physical activity, promote weight loss, and optimise the treatment of comorbidities, or to surgery without structured preoptimisation. The primary endpoint is complications at three months postoperatively. During surgery, biopsies of skin, muscle, and fascia will be collected, along with pre- and postoperative blood samples, to analyse the molecular effects of preoptimisation, particularly in relation to collagen metabolism.

NCT Number	NCT07316426
Lead Sponsor	Umeå University Collaborators: Region Norrbotten, Region Västerbotten
Conditions	Hernia, Hernia, Ventral, Hernia Incisional, Hernia, Umbilical
Enrollment	130 participants
Start Date	2025-09-22
Primary Completion	2027-09-01 (estimated)
Study Completion	2029-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-05