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Chewing Gum Flavors to Reduce Postoperative Nausea and Vomiting After PIPAC

StatusNot Yet Recruiting
PhaseNot applicable
Started
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Record status
This record was last updated January 2, 2026 (before its estimated January 30, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Study First Submitted
This randomized controlled clinical trial aims to evaluate the effectiveness of chewing gum with different natural flavors in reducing postoperative nausea and vomiting (PONV) following Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). Adult patients undergoing PIPAC will be randomly assigned to one of three groups: (1) ginger-mint flavored gum, (2) cinnamon flavored gum, or (3) control group with standard postoperative care only. Participants in the intervention arms will chew one piece of gum for 15 minutes in the post-anesthesia care unit (PACU). Nausea intensity (Numeric Rating Scale, 0-10) and the presence of vomiting or retching will be assessed at baseline and every 15 minutes for 2 hours. The study hypothesizes that ginger-mint and cinnamon flavored chewing gums, both plant-based and certified vegan, will be effective, non-pharmacological, and safe methods to reduce nausea and vomiting after PIPAC. This research may contribute to enhanced postoperative comfort and faster recovery by supporting the principles of Enhanced Recovery After Surgery (ERAS).
Trial Details
NCT Number NCT07315412
Lead Sponsor Fenerbahce University
Collaborators: Istanbul University, Umraniye Education and Research Hospital
Conditions
(from sponsor)		 Postoperative Nausea and Vomiting (PONV), Peritoneal Metastases From Colorectal Cancer, Intraperitoneal Chemotherapy
Related terms Postoperative Nausea and Vomiting, Vomiting
Enrollment 75 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov