A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With Reduced Kidney Function

The purpose of this study is to learn how the study medicine PF-07328948 is processed by the body and how safe and tolerable it is in adults with different levels of kidney function. The study will include participants who: * Are aged 18 to 80 years. * Either have normal kidney function or long-term reduced kidney function (moderate or severe). * Have a BMI (body mass index) of 17.5 to 40 kilogram per meter squared, inclusive, and a total body weight of more than or equal to 45 kilograms or 99 pounds. All participants will receive a single dose of PF-07328948 as a tablet taken by mouth. Participants will stay at a clinical research unit for about 6 days to receive the study medicine and undergo safety checks. Total participation lasts up to 64 days, including screening, inpatient stay, and a follow-up call. The study is not randomized or blinded, meaning all participants and study staff know which treatment is being given. Group assignment is based on kidney function tests done during screening. The results will help researchers understand how reduced kidney function affects the way PF-07328948 works in the body.

NCT Number	NCT07315360
Lead Sponsor	Pfizer
Conditions	Renal Impairment, Healthy
Enrollment	28 participants
Start Date	2026-01-28
Primary Completion	2027-03-13 (estimated)
Study Completion	2027-03-13 (estimated)
Updated on ClinicalTrials.gov	2026-05-12