Impact of Interventional Revascularization on the Physiological Assessment of Bystander Coronary Lesions by FFR

The ABC-FFR trial examines the understudied hemodynamic interaction between parallel coronary stenoses, as the physiological impact of treating one lesion on the pressure indices of lesions in separate parallel branches is not yet fully understood. This prospective, multicenter study enrolls patients scheduled for percutaneous coronary intervention (PCI) of a designated index lesion who also present with a concurrent remote stenosis in a parallel coronary artery. It evaluates potential changes in fractional flow reserve (FFR) and non-hyperemic pressure ratio (NHPR) measurements within the remote lesion both before and after the index lesion is revascularized.

NCT Number	NCT07314879
Lead Sponsor	Friedrich-Alexander-Universität Erlangen-Nürnberg Collaborators: University of Erlangen-Nürnberg Medical School, University Hospital Erlangen
Conditions	Coronary Artery Disease
Enrollment	160 participants
Start Date	2020-06-10
Primary Completion	2025-06-26 (estimated)
Study Completion	2025-06-26 (estimated)
Updated on ClinicalTrials.gov	2026-01-02