Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronary Artery Bypass Grafting

The MICRA-HYBRID trial is a prospective, multicenter, randomized controlled study comparing multivessel hybrid coronary revascularization (HCR) as minimally invasive arterial bypass grafting to left-sided coronary targets (LAD and LCx) plus PCI of the RCA versus conventional off-pump coronary artery bypass grafting (OPCAB) via median sternotomy in patients with three-vessel coronary artery disease. The primary goal is to evaluate whether multivessel-HCR provides superior 30-day "textbook" clinical outcomes (mortality, MI, stroke, re-exploration for bleeding, and other complications) while improving perioperative recovery and long-term cardiovascular outcomes.

NCT Number	NCT07314138
Lead Sponsor	Catharina Ziekenhuis Eindhoven Collaborators: Universitaire Ziekenhuizen KU Leuven, Eindhoven University of Technology
Conditions	Coronary Artery Disease (CAD), Bypass, Cardiopulmonary, Minimally Invasive Coronary Revascularization Surgery, Off-pump Coronary Artery Bypass
Enrollment	250 participants
Start Date	2026-04-01
Primary Completion	2029-05-01 (estimated)
Study Completion	2034-05-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-02