Mode of Ventilation During Critical Illness at Multiple Centers

The goal of this clinical trial is to learn whether the choice of ventilator mode for patients on breathing machines in the intensive care unit affects their survival and recovery. To do this, researchers will assign the entire participating intensive care unit to one of the three available ventilator modes, alternating which mode is assigned in random sequence every 2 months. The main question it aims to answer is: Does the choice between volume control, pressure control, and adaptive pressure control affect the number of days that patients are alive and free of the breathing machine?

NCT Number	NCT07313956
Lead Sponsor	Vanderbilt University Medical Center Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Conditions	Respiratory Failure, Mechanical Ventilation, Critical Illness
Enrollment	4,785 participants
Start Date	2026-05-01
Primary Completion	2030-01 (estimated)
Study Completion	2030-03 (estimated)
Updated on ClinicalTrials.gov	2026-05-06