Study to Enable New Diagnostics for Pulmonary Microbes in People With CF

Sputum culture has been the best approach to detect harmful bacteria in the lungs of people with cystic fibrosis (CF). With the widespread use of new CF therapies (like Trikafta and Alyftrak), it is more difficult for people with CF to produce sputum even though they still have harmful bacteria in their lungs. The SEND-CF study is being done to see if there are other ways to detect harmful bacteria in the lungs.

NCT Number	NCT07312734
Lead Sponsor	Chris Goss Collaborators: Cystic Fibrosis Foundation, University of Pennsylvania
Conditions	Cystic Fibrosis (CF), New Diagnostics
Enrollment	300 participants
Start Date	2026-03-30
Primary Completion	2027-08-01 (estimated)
Study Completion	2027-08-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-02